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Could an Experimental Memory Drug Put an End to “Senior Moments”?

 
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From: Discover Magazine Online: A new drug seems to be able to reverse normal age-related memory decline in old mice–like a face-lift for neurons, bringing them back to their younger days. The results of the experimental treatment, which works by blocking certain stress hormones, were published in the Journal of Neuroscience. “What’s most surprising is […]

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Posted October 21, 2010 by Bernard J. Baars

 
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From: Discover Magazine Online:

A new drug seems to be able to reverse normal age-related memory decline in old mice–like a face-lift for neurons, bringing them back to their younger days. The results of the experimental treatment, which works by blocking certain stress hormones, were published in the Journal of Neuroscience.

“What’s most surprising is that even short-term inhibition was able to reverse memory loss in old mice,” says Jonathan Seckl, a professor of molecular medicine who was involved in the research. “I don’t think people had realized this was so reversible. It takes [the animals] back to being relatively young.” [Technology Review].

Research has shown that stress hormones called glucocorticoids play a role in memory loss, by damaging the brain over time. But targeting the glucocorticoids themselves is dangerous, because reducing their levels would leave the body without a stress response. The researchers therefore targeted an enzyme instead, which activates the hormone in neurons.

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Bernard J. Baars

 


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